CORDIS Project
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This project aims to develop tricyclic peptides that can effectively bind to flat protein surfaces, enhancing therapeutic applications. By utilizing phage display technology, the research focuses on generating high-affinity peptide antagonists for cancer-related proteins and antibiotic targets.
Peptide macrocycles can bind with high affinity and selectivity to protein targets and are an attractive class of molecules for the development of therapeutics.
Recently, a phage display-based strategy was developed that allowed to generate potent bicyclic peptide antagonists (Heinis, C., et al., Nat.
Chem.
Biol., 2009).
While bicyclic peptides with nanomolar affinities to a range of protein targets could be generated, it was more difficult to obtain high-affinity binders to some proteins, parti…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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