CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
The project explores the effects of free radicals on DNA, specifically focusing on a unique type of damage to guanine. It aims to understand the chemical properties and biological implications of this damage in relation to aging and disease.
Free radical attack to genetic material leads to damages that are involved in pathologies as well as in aging.
Guanine is the preferred oxidation site of DNA, and 8-oxo-dG is used as marker of radical stress, with some drawbacks due to oxidative artefacts during the analysis.
The project addresses the chemical biology of 5’,8-cyclo-2’-deoxyguanosine (5’,8-cyclo-dG), a tandem damage produced by free radical insult to the 5’ position of the sugar.
The compound has an extra covalent bond between th…
CONSIGLIO NAZIONALE DELLE RICERCHE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
