CORDIS Project
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This research project investigates the secondary metabolites of the fungal endophyte Cyanodermella asteris by analyzing specific gene clusters. It involves engineering bacterial and fungal hosts to express these genes, followed by advanced techniques to identify and characterize the resulting compounds.
In the proposed research I aim to explore the secondary metabolome of the newly identified fungal endophyte Cyanodermella asteris.
In this regard, we have selected two in silico-predicted polyketide synthase gene clusters, which will be further examined.
The selected gene clusters thereof are chosen for vector construction in Escherichia coli and subsequently the heterologous expression in fungal hosts (Aspergillus niger or Aspergillus nidulans) will be performed.
Afterwards, the engineered expr…
TECHNISCHE UNIVERSITAET DRESDEN
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