CORDIS Project
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The CURIES project aims to develop a microfluidic bladder-on-chip system that mimics the human bladder's biomechanical and chemical environment. This technology will help researchers understand bacterial interactions during urinary tract infections and contribute to the design of targeted therapies to combat antibiotic…
Urinary tract infections (UTI) are severe bacterial infections of the urinary system.
Low understanding of specific bacteria-host interactions and associated disease aetiologies has led to global misuse of antibiotics driving bacterial resistance.
However, relevant human modelling platforms that replicate all parameters of a physiological bladder and reciprocate infection conditions are non-existent.
During infection bladder stretch-mechanisms are commandeered by opportunistic bacteria to penetr…
KOBENHAVNS UNIVERSITET
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