CORDIS Project
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This project investigates the role of long non-coding RNAs in the pathogenesis of Inflammatory Bowel Diseases, specifically Crohn’s Disease. By analyzing tissue samples, it aims to identify specific targets for therapeutic intervention to promote mucosal healing.
The Inflammatory Bowel Diseases (IBD), Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic/relapsing disorders that affect over six million individuals worldwide.
Mucosal ulcers, the hallmark of CD, are the result of a complex interaction between microbiota, immune cells, and gut epithelia.
Healing of mucosal ulcers is associated with better outcomes, but is achieved in less than half of cases.
Past attempts to suppress central and conserved nodes of the immune system failed due to oppo…
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
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