CORDIS Project
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This project investigates how cytotoxic T lymphocytes and natural killer cells induce cell death in target cells, focusing on the role of reactive oxygen species in this process. The research aims to clarify the molecular events triggered by these immune cells during apoptosis, which is crucial for understanding immune…
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells release granzyme and perforin from cytotoxic granules into the immune synapse to induce apoptosis of target cells that are either virus-infected or cancerous.
Granzyme A activates a caspase-independent apoptotic pathway and induces mitochondrial damage characterized by superoxide anion production and loss of the mitochondrial transmembrane potential, without disrupting the integrity of the mitochondrial outer membrane; while causing sin…
UNIVERSITE DE GENEVE
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