CORDIS Project
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This research examines how the CCCTC-binding factor (CTCF) maintains genome stability during aging. It investigates the role of CTCF in regulating cellular homeostasis and its influence on mutation susceptibility in the mammalian genome.
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Genome stability is one of the most important features in maintaining tissue homeostasis throughout the human lifespan.
The research presented here will dissect how the insulator protein CCCTC-binding factor (CTCF), a ubiquitous 11 zinc finger transcription factor, controls the stability of the mammalian genome during ageing..
In Aim 1, we will elucidate how CTCF and tissue-specific master regulators maintain the functional stability of the genome during healthy ageing by developing a nove…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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