CORDIS Project
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This project aims to determine the structures of beta3 and alpha adrenergic receptors to enhance understanding of their function. The findings will contribute to drug development by elucidating how ligand binding affects receptor activity.
Crystal structures of beta1 and beta2 adrenergic G protein-coupled receptors (GPCRs) have been determined recently.
We propose to extend the structural information about this physiologically and medically important GPCR subfamily by obtaining the structures of the beta3 and the alpha adrenergic receptors.
The ample experience in GPCR structural biology of the host laboratory, complemented by its multidisciplinary approach, provides an ideal environment for this challenging task.
We will make use…
PAUL SCHERRER INSTITUT
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