CORDIS Project
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This project focuses on developing a non-invasive imaging technique to visualize mucus containing specific crystals associated with asthma and other respiratory conditions. The goal is to create a biomarker for personalized treatment using crystal-dissolving antibodies.
Asthma is characterized by airway obstruction, causing difficulty in breathing.
The major cause of therapy resistant obstruction is mucus plug buildup in 60% of severe asthmatics.
Mucus plugs form as a result of abnormal mucus production by airway barrier cells and recruitment of eosinophils that change the mucus from a gel- to a glue-like state.
Eosinophils also release galectin-10 (Gal10) protein, which crystallizes and forms Charcot-Leyden crystals (CLC).
My advanced ERC grant unraveled how C…
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