CORDIS Project
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The cryoNERVE project aims to develop advanced imaging techniques to study the structure and function of myelinated axons in native nerve tissues. By utilizing cryo-electron tomography, the project seeks to understand the role of membrane-shaping proteins in axon health and investigate the molecular basis of hereditary…
Myelinated axons propagate action potentials across otherwise unsurmountable distances.
The overarching hypothesis of the cryoNERVE project is that membrane morphology crucially determines axonal health and function.
Mutations in genes coding for membrane-shaping proteins are the major cause of familial axonopathies like hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth (CMT) disease.
However, current techniques lack the resolution to ascertain the functions of these proteins and their…
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
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