CORDIS Project
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This project focuses on developing a nanofluidic chip for cryogenic transmission electron microscopy, enabling high-resolution imaging of biological macromolecules. The technology aims to improve sample preparation by minimizing sample consumption and controlling ice thickness, facilitating time-resolved imaging for dr…
Cryogenic transmission electron microscopy (cryo-EM) is a technique for high-resolution imaging of radiation-sensitive biological macromolecules under near-native conditions.
Cryo-EM sample preparation techniques rely on rapid cooling of an aqueous suspension of biological macromolecules to obtain a thin layer of amorphous ice containing the solute.
Problems associated with current implementations are considered a major bottleneck to realizing the full potential of cryo-EM: excessive sample cons…
TECHNISCHE UNIVERSITEIT DELFT
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