CORDIS Project
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This project studies DNA replication in eukaryotic cells, focusing on how nucleosomes are dismantled and reassembled during the process. It aims to understand the molecular mechanisms that ensure proper gene expression and epigenetic inheritance.
DNA replication is essential for cell proliferation.
In eukaryotic cells, DNA is densely packaged in nucleosome arrays that form chromatin.
Such organisation protects the genetic material and controls access to DNA, thus providing an important mechanism for regulating gene expression.
The eukaryotic replication machinery has evolved to unravel nucleosomes in order to access and duplicate DNA, while also maintaining chromatin density on newly duplicated DNA.
To achieve this, the replisome dismant…
THE FRANCIS CRICK INSTITUTE LIMITED
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