CORDIS Project
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This research investigates the role of the OPA1 protein in mitochondrial function and its implications for autosomal dominant optic atrophy. By understanding how OPA1 regulates cellular processes, the project aims to identify potential therapeutic targets for treating this condition.
Autosomal dominant optic atrophy (ADOA) is caused by mutations in Optic Atrophy 1 (OPA1), a dynamin-related protein of the inner mitochondrial membrane.
During the last years, we clarified that OPA1 is a multifunctional protein participating in genetically distinct pathways of mitochondrial fusion and cristae remodelling, both impaired by pathogenetic mutations.
We extended our investigation on the (dys)function of OPA1 and our preliminary results indicate that (i) OPA1 is a key modulator of apo…
UNIVERSITA DEGLI STUDI DI PADOVA
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