CORDIS Project
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This project focuses on understanding the mechanisms of histone deacetylase inhibitors in cancer treatment. By developing targeted tools, it aims to clarify how these drugs affect gene expression and chromatin structure, potentially improving therapeutic outcomes.
Cancer is responsible for 8.5 million deaths worldwide each year, representing a considerable burden for society.
In cancer cells, tumor repression genes are deactivated by epigenetic mechanisms.
The accessibility of DNA to transcription factors is determined in part by the chemical modifications of histones, proteins that pack DNA into condensed chromatin.
When histones are deacetylated by histone deacetylases (HDACs), the chromatin structure is even more packed, preventing gene expression. HDA…
UNIVERSITE DE GENEVE
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United States, New York
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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