CORDIS Project
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This project investigates the CRISPR system, a bacterial defense mechanism, to identify phage genes that can counteract it. By characterizing these genes, the project aims to enhance phage therapy against bacterial pathogens and understand the interactions within the CRISPR system.
The CRISPR system was recently identified as a bacterial defense mechanism against phages and plasmids.
The CRISPR system is composed of DNA arrays containing short sequences identical to those present in phages and plasmids.
These short DNAs are transcribed and processed by CRISPR associated proteins that also guide other CRISPR proteins to target the invading DNA.
Only a few of the CRISPR components have been characterized to date and their mechanism of action is still largely unknown.
Phage d…
TEL AVIV UNIVERSITY
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