CORDIS Project
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This project aims to enhance CRISPR technology by developing high-throughput screening methods that can target multiple genes simultaneously. By utilizing CRISPR arrays, the project seeks to unravel genetic redundancy in biological processes, potentially transforming our understanding of gene interactions.
A ubiquitous yet poorly understood theme pervading biology is redundancy, wherein seemingly equivalent components drive shared processes.
In cases from development to pathogenesis, untangling the ensuing web of potential genetic interactions can be virtually impossible with conventional techniques. CRISPR technologies, with their propensity for multiplexing, are well poised to address this challenge.
However, current CRISPR-based screens have not exceeded more than two targets at a time.
Here, I…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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