CORDIS Project
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This project investigates the use of CRISPR-Cas9 technology to edit specific DNA sequences that form G-quadruplex structures, which can inhibit gene expression. The focus is on understanding how these structures affect genes linked to various diseases and exploring potential therapeutic applications.
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) have recently been at the forefront of genomic research due to their enormous potential at editing the genome with great precision and specificity. A world-wide effort is currently underway to test Cas proteins and their variants for applications geared towards genome editing for human cells.
How CRISPR-Cas systems perform in editing sequences that form non-canonical DNA or RNA secondary struc…
TECHNISCHE UNIVERSITEIT DELFT
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