CORDIS Project
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This project explores the role of lipid antigens presented by CD1 proteins in T cell responses, particularly in the context of Group A Streptococcus infections. It aims to uncover mechanisms that could lead to therapeutic strategies for preventing autoimmune diseases linked to these infections.
Most T cell immunology knowledge is centered on T cell receptor (TCR) recognition of peptides presented by major histocompatibility complex (MHC) molecules. MHC class I-like CD1 proteins present lipid antigens to T cells, but it is becoming increasingly clear that the rules of lipid engagement show fundamental divergence from those of peptide recognition.
As CD1 proteins are relatively monomorphic, solving the fundamental biology of lipid recognition opens the potential for wide therapeutic bene…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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