CORDIS Project
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This project investigates the role of ryanodine receptors in cardiac myocytes to understand their function in heart rhythm regulation. It aims to explore how the organization of these receptors may contribute to arrhythmias, particularly in chronic atrial fibrillation.
Synchronized release of Ca2+ from the internal Ca2+ store of cardiac myocytes, the sarcoplasmic reticulum, is essential for a normal heart beat.
This is obtained through a sophisticated subcellular organization, the dyad.
In dyads, a cluster of release channels in the sarcoplasmic reticulum, ryanodine receptors or RyRs, face Ca2+ channels in the cell membrane, the dihydropyrydine receptors or DHPRs. DHPRs provide the Ca2+ influx that triggers opening of RyR.
Ca2+ release can also propagate betwe…
KATHOLIEKE UNIVERSITEIT LEUVEN
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