CORDIS Project
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This project aims to uncover the molecular mechanisms regulating collagen trafficking, which is vital for tissue development and health. By employing advanced methodologies, it seeks to understand how specific proteins influence vesicular transport and their implications for collagen-related diseases.
Collagen maturation (through post-translational modifications, quaternary assembly and transport) is critical for tissues and organ development and homeostasis.
This complex process involves numerous actors in different sub-cellular compartments, which in turn depend on highly regulated trafficking systems.
Although the mechanisms of vesicular trafficking, membrane tethering and fusion are conserved throughout eukaryotic evolution, highly specialized tethering complexes have evolved to regulate…
UNIVERSITA DEGLI STUDI DI PAVIA
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