CORDIS Project
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This project investigates the genetic and cellular mechanisms behind the development and folding of the mammalian cerebral cortex, using ferrets as a model. Understanding these processes is crucial for grasping how cortical structure impacts brain function and may inform studies on intellectual impairments linked to co…
The mammalian cerebral cortex was subject to a dramatic expansion in surface area during evolution.
This process is recapitulated during development and is accompanied by folding of the cortical sheet, which allows fitting a large cortical surface within a limited cranial volume. A loss of cortical folds is linked to severe intellectual impairment in humans, so cortical folding is believed to be crucial for brain function.
However, developmental mechanisms responsible for cortical folding, and t…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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