CORDIS Project
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This project aims to analyze cell division in mouse embryos to understand the causes of aneuploidy, which can lead to developmental issues. Using advanced imaging techniques, it seeks to identify the molecular mechanisms behind cell division errors and their implications for embryonic development.
Cell division is fundamental for development.
In the early mammalian embryo it drives the rapid proliferation of totipotent cells, the basis for forming the fetus.
Given its crucial importance, it is surprising that cell division is particularly error-prone at the beginning of mammalian life, resulting in spontaneous abortion or severe developmental retardation, the incidence of which is increasing with age of the mother.
Why aneuploidy is so prevalent and how early embryonic development neverth…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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