CORDIS Project
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This project explores the role of coronin 1 in T-cell homeostasis, particularly under low cell density conditions. It aims to elucidate the molecular mechanisms behind this process, which is crucial for maintaining immune function.
Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex.
However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD rep…
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