CORDIS Project
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This project explores the interaction between bacterial pathogens and their prophages, focusing on how this relationship affects virulence during infections. It aims to uncover the regulatory mechanisms that allow bacteria to coexist with phages, potentially informing new therapeutic strategies.
Most bacterial pathogens are lysogens, namely carry DNA of active phages within their genome, referred to as prophages.
While these prophages have the potential to turn under stress into infective viruses which kill their host bacterium in a matter of minutes, it is unclear how pathogens manage to survive this internal threat under the stresses imposed by their invasion into mammalian cells.
In the proposed project, we will study the hypothesis that a complex bacteria-phage cooperative adaptatio…
TEL AVIV UNIVERSITY
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