CORDIS Project
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This project investigates the role of Constitutive morphogenetic protein 1 (Cop1) in tumor suppression, particularly in T-cell lymphomas and prostate cancer. It focuses on how the protein influences mitochondrial morphology and its implications for cell death and DNA damage during tumor formation.
The Constitutive morphogenetic protein 1 (Cop1) is an E3-ubiquitin ligase regulating stability of a broad group of targets with pleiotropic functions.
Cop1 emerged as a tumour suppressor in T-cell lymphomas and in prostate cancer.
During tumour formation, mitochondria are key organelles regulating cell death and proliferation.
This multiplicity of functions is mirrored by the complex morphology of the organelle, resulting from the equilibrium between fusion and fission, events controlled by a se…
UNIVERSITE DE GENEVE
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