CORDIS Project
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This project investigates how promoter elements influence the recruitment of splicing regulators known as SR proteins and their impact on pre-mRNA splicing outcomes. By utilizing innovative techniques, it aims to enhance understanding of the relationship between transcription and splicing, particularly in neuronal diff…
Accurate pre-mRNA splicing is a fundamental step for gene expression. SR proteins, a protein family of splicing regulators, play an essential role in the process by defining intron-exon boundaries and recruiting the spliceosome to carry out splicing.
Pre-mRNA splicing occurs co-transcriptionally and it is now emerging that promoter identity modulates alternative splicing, possibly through the recruitment of SR proteins or through kinetic coupling by altering Pol II elongation rates.
The aim of t…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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