CORDIS Project
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This research explores the DNA damage response during meiosis in Drosophila, focusing on how persistent DNA breaks affect cell cycle progression and gene expression. It aims to uncover the genetic mechanisms that regulate chromatin integrity and developmental processes.
DNA damage response (DDR) monitors chromosome status to ensure correct homologous recombination, genomic integrity and chromosome segregation.
Thus the effect of DDR activation upon exogenous DNA breaks has been intensely studied.
Less is known about the effects of such mechanisms due to endogenous breaks.
In multicellular organisms meiosis is a classical example of double strand break (DSB) production and repair occurring concomitantly with gamete development.
In Drosophila persistent meiotic D…
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