CORDIS Project
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This project investigates the role of tRNA-fragments in Huntington's disease, focusing on their interaction with stress granules and mutant huntingtin aggregates. The research aims to identify potential therapeutic targets and understand the molecular mechanisms underlying disease progression using various models and a…
Many pathogenic mechanisms are involved in Huntington’s disease (HD), the most prevalent monogenic neurological disease in Europe, with no current cure.
The host team reported a dysregulation of tRNA-fragments (tRFs) in HD brains; other studies showed higher stress granules' (SG) density in HD, and that tRFs promote SG assembly.
Thus, my hypothesis is that HD-related tRFs contribute to the accumulation of SG, initiating mutant huntingtin (mtHTT) aggregation and leading to disease pathogenesis. I…
UNIVERSITAT DE BARCELONA
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