CORDIS Project
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This project investigates how an abnormal number of chromosomes affects blood cell formation and mutation accumulation in children with Down's Syndrome. By analyzing human fetal tissue and using advanced sequencing techniques, it aims to uncover mechanisms that may lead to increased leukemia risk in these individuals.
Many childhood leukaemias start to develop before birth due to accumulation of mutations during foetal development.
Children with trisomy of chromosome 21 (Ts21), also known as Down's Syndrome (DS), have a 500-fold increased chance of developing acute megakaryoblastic leukaemia.
It is well known that aneuploidy (an abnormal number of chromosomes) is often associated with leukaemia and is likely to be driving this increased incidence of blood malignancies in children with DS.
However, the mechani…
KOBENHAVNS UNIVERSITET
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