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The CONTACT project develops a three-dimensional bioengineered model of triple negative breast cancer to better understand how cancer cells adapt to chemotherapy. This model aims to mimic the tumor microenvironment, enabling researchers to study the mechanisms behind drug tolerance and improve personalized treatment st…
Triple Negative Breast Cancer is the most aggressive among breast cancer subtypes.
The conventional neo-adjuvant therapy is ineffective in about 50% of cases, with patients presenting a higher risk of recurrence and metastasis.
The failure of the currently available chemotherapeutic strategy is also due to the lack of cancer preclinical models that are “close-to-reality” and therefore able to accurately recapitulate the tumor microenvironment, the transcriptional reprogramming and the cancer cel…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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