CORDIS Project
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This study examines the signaling mechanisms of G protein-coupled receptors (GPCRs) and their regulatory proteins in zebrafish. It aims to understand how mutations affect heart development by investigating the interactions between specific receptors and their signaling pathways.
7TM receptors are called GPCRs because they require interaction with heterotrimeric G proteins to signal.
In humans the family of GPCRs is comprised of more than 800 members.
Despite their large number, GPCRs share high sequence homology and rely on an amazingly small assortment of accessory molecules to regulate their ability to signal.
One such regulatory protein family is the family of G protein-coupled receptor kinases (GRK), which consists of seven isoforms. GRKs provide the rate limiting m…
UNIVERSITAET ULM
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