CORDIS Project
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This project investigates how transcription factors regulate gene expression across different species. By comparing human and mouse tissues, it aims to uncover conserved mechanisms that govern cell identity and function, focusing on a specific type of liver cell.
Vertebrates contain hundreds of different cell types which maintain phenotypic identity by a combination of epigenetic programming and genomic regulation.
Systems biology approaches are now used in a number of laboratories to determine how transcription factors and chromatin marks pattern the human genome.
Despite high conservation of the cellular and molecular function of many mammalian transcription factors, our recent experiments in matched mouse and human tissues indicates that most transcri…
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