CORDIS Project
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This project focuses on the endoplasmic reticulum-nuclear envelope junctions in eukaryotic cells, essential for inter-organelle communication. It aims to uncover the molecular mechanisms that govern these structures, which are crucial for nuclear function and cellular health.
Compartmentalization into membrane-bound organelles is a key feature of all eukaryotic cells, and communication between organelles needs to be tightly controlled. A key organelle for the inter-organelle communication is the endoplasmic reticulum (ER), which is the major site of lipid and membrane protein synthesis.
The ER exchanges molecules by forming stable contact sites with multiple organelles such as mitochondria via specific tethering proteins and transporters.
In contrast to these contact…
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