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The CONNECT-2-CLINIC project focuses on developing specific inhibitors for Pannexin1 channels, which play a role in cell death and inflammation. By creating targeted nanobodies, the project aims to provide therapeutic solutions for liver diseases, enhancing the potential for clinical applications.
Pannexin1 (Panx1) channels mediate the exchange of biochemical messengers between the cytosol of a cell and its extracellular environment.
This type of cellular communication underlies cell death and inflammation, both which are associated with a plethora of diseases.
Closing pannexin channels therefore seems an interesting therapeutic strategy.
In this respect, the ERC Starting Grant project CONNECT has demonstrated that peptide-based inhibition of Panx1 channels counteracts the manifestation o…
VRIJE UNIVERSITEIT BRUSSEL
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