CORDIS Project
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This research focuses on understanding the early changes in neuron behavior associated with neurodegenerative diseases, specifically Spinocerebellar ataxia type 1. By investigating the molecular mechanisms of neuron degeneration, it aims to develop new therapeutic strategies for various neurodegenerative conditions.
Neurodegenerative diseases (NDs) are incurable, debilitating conditions, arise mid-late in life, represent an enormous health and socioeconomic burden and no therapies exist.
An enigmatic finding in NDs is the early and selective alteration in intrinsic excitability of vulnerable neurons paralleling changes in its circuitry.
However, a gap in understanding exists in ND field about the cause of these alterations and whether these modifications regulate degenerative pathomechanisms.
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