CORDIS Project
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This project investigates how Staphylococcus aureus evades the immune response, particularly through complement proteins. It aims to develop antibody-based therapies that can neutralize these evasion mechanisms and reduce inflammation caused by bacterial infections.
Staphylococcus aureus is a widely disseminated human pathogen whose virulence is associated with a broad range of severe and potentially fatal health complications.
It has been shown to produce a series of immunomodulators that promote virulence by affecting both arms of the host immune response.
Complement (C’) represents a key innate immune effector that protects against infection, and S. aureus has evolved several strategies to evade C’ neutralization. C’ proteins are essential for the propag…
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