CORDIS Project
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This project focuses on understanding the interplay between DNA methylation and Polycomb Repressive Complexes in cancer cells. By employing a new methodology for simultaneous profiling, it aims to characterize epigenetic changes throughout the tumorigenic process.
Epigenetics refers to heritable changes in gene expression patterns, brought about by modifications to DNA and chromatin.
Aberrant epigenetic activity was shown to play important roles in the tumorigenic process.
Two major epigenetic systems are known:
DNA methylation and the histone modification machinery, an important component of which is the Polycomb Repressive Complexes (PRC) system.
Recent works have suggested that a link between the two systems exists in cancer cells.
Previous work on the…
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
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