CORDIS Project
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This project aims to tackle antibiotic resistance by studying polyketide synthases, large enzyme complexes that produce antibiotics. By enhancing understanding of their structure and function, the project seeks to enable the design of new antibiotics to combat resistant bacterial infections.
Multidrug resistant bacteria that render worthless the current arsenal of antibiotics are a growing global problem.
This grave challenge could be tackled by polyketide synthases (PKSs), which are gigantic modular enzymatic assembly lines for natural products. PKSs could be developed for industry to produce chemically difficult to synthesize drugs, but cannot be harnessed until we understand how they work on the molecular level.
However, such understanding is missing because we cannot easily inve…
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