CORDIS Project
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This project investigates the molecular mechanisms of nonsense-mediated mRNA decay (NMD), focusing on how cells identify and degrade faulty messenger RNA. By employing advanced techniques, the research aims to enhance understanding of mRNA quality control, which is crucial for addressing genetic diseases linked to NMD.
Nonsense-mediated mRNA decay (NMD) is an essential mechanism controlling translation in the eukaryotic cell. NMD ascertains accurate expression of the genetic information by quality controlling messenger RNA (mRNA).
During translation, NMD factors recognize and target to degradation aberrant mRNAs that have a premature stop codon (PTC) and that would otherwise lead to the production of truncated proteins which could be harmful for the cell. A wide range of genetic diseases have their origin in t…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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