CORDIS Project
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This project investigates the mechanisms of enzymatic nucleophilic substitution reactions, focusing on the role of metal ions and protein environments. By utilizing advanced chemical reactivity theories, it aims to enhance understanding of these biochemical processes, particularly in energy transduction and sulfur oxid…
Enzymatic nucleophilic substitution reactions are ubiquitous as key steps in biochemical processes of living cells.
Despite their importance, they are poorly understood, in particular regarding the exact mechanism and involvement of the protein environment and the role and mechanistic involvement of metal ions.
Through interpretative methods from chemical reactivity theory, I will tackle the missing links in this field of molecular life sciences.
This project thus goes beyond transition state c…
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