CORDIS Project
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This project explores the role of specific genes involved in epigenetic regulation and their mutations in cancer development. By employing advanced techniques, it aims to uncover how these mutations affect cell behavior and identify potential therapeutic targets in cancer treatment.
Epigenetic features are commonly dysregulated in cancer and one of the surprising findings from the sequencing of cancer genomes is the high rate of alterations in many epigenetic regulators. KMT2D/MLL4, KMT2C/MLL3 and KDM6A/UTX are among the most frequently mutated genes in a wide range of cancers and in normal aged epithelial cells.
Interestingly, these three genes are components of the same complex, COMPASS-like complex that regulate enhancer activity and regulate gene expression in a lineage…
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