CORDIS Project
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This project investigates the protein secretion mechanisms of the bacterial pathogen Campylobacter jejuni. It aims to identify the proteins secreted during infection and understand their roles in host cell interactions, potentially leading to new targets for vaccines and treatments.
Bacterial pathogens often secrete proteins into their environment to institute infection of eukaryotic host cells.
Common virulence-associated protein secretion machineries are the well studied type III and IV systems that facilitate proteins to associate with and translocate into eukaryotic cells.
The principal bacterial food-borne pathogen Campylobacter jejuni and related species lack these systems but seem to have evolved alternative protein secretion strategies.
So far, a few Campylobacter v…
UNIVERSITEIT UTRECHT
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