CORDIS Project
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This project investigates the effects of a novel drug, compound 21, and melatonin on cardiovascular remodeling in hypertensive rats. By targeting the type 2 angiotensin receptor, the study aims to enhance treatment strategies for hypertension and related cardiovascular diseases.
Cardiovascular (CV) diseases are the major source of morbidity and mortality in the EU with annual costs of € 169 billion.
The control of hypertension and prevention of left ventricular (LV) hypertrophy and fibrosis, which could interrupt the CV continuum, still remain insufficient world-wide. A substantial part of current therapies modulate the renin-angiotensin system (RAS) and decrease the unfavorable stimulation of angiotensin type 1 receptors (AT1R).
Results of the host group indicate that…
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