CORDIS Project
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This project aims to develop new therapeutic strategies for Amyotrophic Lateral Sclerosis by targeting a specific genetic mutation. It focuses on creating chemical agents that can counteract the toxicity of RNA associated with the disease.
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder that occurs in families, and sporadically in individuals.
It was recently discovered that the massive expansion of a GC-rich hexanucleotide in the intron of the gen C9orf72 is its most frequent genetic cause.
Many efforts have been dedicated to decipher the mechanisms by which this repeat expansion contributes to the disease.
Although not completely understood, the most prominent mechanism suggested is the toxicity mediated by b…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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Canada, Montreal
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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