CORDIS Project
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This project investigates how the immune system's complement proteins kill bacteria. By studying the enzymes involved in this process, the research aims to reveal the mechanisms of bacterial destruction and enhance therapeutic strategies against infections.
This proposal aims to provide insight into how bacteria are killed by the complement system, an important part of the host immune response against bacterial infections.
Complement is a large protein network in plasma that labels bacteria for phagocytosis and directly kills them via the formation of a pore-forming complex (Membrane Attack Complex (MAC)).
Currently we do not understand how complement activation results in bacterial killing.
This knowledge gap is mainly caused by the lack of tools…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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