CORDIS Project
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This project investigates the genetic mutations involved in colorectal cancer, particularly focusing on the Adenomatous Polyposis Coli gene. It aims to develop mouse models that mimic human disease to test new therapeutic strategies.
Colorectal cancer (CRC) is one of the most common cancers of the western world.
The underlying initiating mutation for the majority of CRC is within the Adenomatous Polyposis Coli (Apc) gene.
The APC protein performs an important role in controlling the levels of Wnt signalling by targeting beta-catenin for degradation.
Loss of the APC protein leads to the activation of Wnt signaling target genes such as c-Myc which is required for phenotypes causes by Apc loss.However, despite the clear importa…
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