CORDIS Project
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This project explores the synchronization of signaling oscillations during the early development of vertebrate embryos. It aims to understand how these oscillations contribute to the formation of body structures by studying the interactions in specific embryonic cells.
In this proposal, we study collective signaling oscillations during embryonic patterning.
Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997).
The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos).
Importantly, PSM cells display complex, collective synchronization and, as a resu…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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