CORDIS Project
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This project investigates the mechanisms of sister chromatid cohesion during cell division, focusing on the role of cohesin complexes. It aims to enhance understanding of chromatin organization and gene regulation, with implications for genetic disorders.
During S-phase newly synthesized “sister” DNA molecules become physically connected.
This sister chromatid cohesion resists the pulling forces of the mitotic spindle and thereby enables the bi-orientation and subsequent symmetrical segregation of chromosomes.
Cohesion is mediated by ring-shaped cohesin complexes, which are thought to entrap sister DNA molecules topologically.
In mammalian cells, cohesin is loaded onto DNA at the end of mitosis by the Scc2-Scc4 complex, becomes acetylated during…
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