CORDIS Project
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CohesiNet investigates the cohesin protein complex, which is crucial for DNA organization, chromosome segregation, and gene regulation. The project aims to uncover the molecular mechanisms of cohesin functions and their links to developmental disorders and cancer, using innovative research methods and fostering collabo…
Cohesin is an evolutionarily conserved multi-protein complex that belongs to the structural maintenance of chromosomes protein family.
It can topologically entrap DNA molecules mediating sister chromatid cohesion, a function important for accurate chromosome segregation and DNA replication/repair.
It has been recently discovered that cohesin can generate and maintain DNA loops by an ATPase-dependent in cis DNA tethering activity, called loop-extrusion, critical for organising chromatin architect…
CONSIGLIO NAZIONALE DELLE RICERCHE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Portugal, Lisboa
Type: Research institute
Activity type: Research Organisations
SME: No
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria, Wien
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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