CORDIS Project
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This project investigates how DNA double-strand breaks are repaired in cells, focusing on the roles of cohesin complexes in determining the repair pathway. Using the model organism Caenorhabditis elegans, it aims to clarify the mechanisms of DNA damage response, particularly in germ cells, to enhance understanding of g…
DNA double-strand breaks (DSBs) are the most hazardous type of DNA damage threatening genomic stability.
Thus, eukaryotes developed different mechanisms of DNA damage response and DNA repair pathways which are highly conserved, but not fully understood.
To keep a control between error-prone (Non-Homologous End-Joining, NHEJ) and high-fidelity (Homologous Recombination, HR) mechanisms of DSB repair is essential for cell fitness, mainly exerted at the level of licensing HR by the initial step of t…
UNIVERSIDAD DE SEVILLA
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